Insulin Resistance and Hypertension Mechanism in the Pathogenesis of Obesity-Associated Microvascular Dysfunction in Obesity: A Potential
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[PDF] [Full Text] [Abstract] , December , 2010; 299 (6): E947-E952. Am J Physiol Endocrinol Metab Porzio, Davide Lauro and Carmine Cardillo Francesca Schinzari, Manfredi Tesauro, Valentina Rovella, Angelica Galli, Nadia Mores, Ottavia obesity-related metabolic syndrome Generalized impairment of vasodilator reactivity during hyperinsulinemia in patients with [PDF] [Full Text] [Abstract] , February , 2011; 96 (2): 438-446. JCEM Jia Liu, Linda A. Jahn, Dale E. Fowler, Eugene J. Barrett, Wenhong Cao and Zhenqi Liu Microvasculature in Humans Free Fatty Acids Induce Insulin Resistance in Both Cardiac and Skeletal Muscle [PDF] [Full Text] , May , 2011; 34 (Supplement 2): S342-S348. Dia Care Smulders and Coen D. Stehouwer Amy M. Jonk, Alfons J. Houben, Nicolaas C. Schaper, Peter W. de Leeuw, Erik H. Serné, Yvo M. potential mechanism in the pathogenesis of obesity-related insulin resistance Meal-Related Increases in Microvascular Vasomotion Are Impaired in Obese Individuals : A [PDF] [Full Text] [Abstract] , August , 2011; 301 (2): H418-H427. Am J Physiol Heart Circ Physiol Towse, Jane A. Kent-Braun and Bruce M. Damon Otto A. Sanchez, Elizabeth A. Copenhaver, Marti A. Chance, Michael J. Fowler, Theodore F. subjects in a muscle-specific manner Postmaximal contraction blood volume responses are blunted in obese and type 2 diabetic [PDF] [Full Text] [Abstract] , September , 2011; 301 (3): H689-H695. Am J Physiol Heart Circ Physiol Christopher A. DeSouza Brian R. Weil, Christian M. Westby, Gary P. Van Guilder, Jared J. Greiner, Brian L. Stauffer and Enhanced endothelin-1 system activity with overweight and obesity
منابع مشابه
Microvascular dysfunction: a potential mechanism in the pathogenesis of obesity-associated insulin resistance and hypertension.
The intertwined epidemics of obesity and related disorders such as hypertension, insulin resistance, type 2 diabetes, and subsequent cardiovascular disease pose a major public health challenge. To meet this challenge, we must understand the interplay between adipose tissue and the vasculature. Microvascular dysfunction is important not only in the development of obesity-related target-organ dam...
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متن کاملMeal-Related Increases in Microvascular Vasomotion Are Impaired in Obese Individuals
Obesity is associated with insulin resistance, hypertension, cardiovascular disease, and type 2 diabetes (1), but the mechanisms underlying these associations are incompletely understood. This article reviews and adds original data (i.e., in the postprandial state) to the evidence for microvascular dysfunction, including impairment of insulin-stimulated microvascular perfusion as a key element ...
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متن کاملImpaired microvascular function in obesity: implications for obesity-associated microangiopathy, hypertension, and insulin resistance.
BACKGROUND Obesity is associated with an increased risk of developing microangiopathy, hypertension, and insulin resistance. We hypothesized that obesity is a primary cause of microvascular dysfunction, which may contribute to the development of these obesity-related disorders. METHODS AND RESULTS We examined microvascular function in 16 lean (body mass index <24 kg/m2) and 12 obese (body mas...
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